Pre-Workout-Focus Matrix Formula- Contains Creatine, Citrulline (Fruit Punch)

Description

 

Formula Purposes & Benefits

Pre-Workout-Focus Matrix Formula- Contains Creatine, Citrulline (Fruit Punch) is synthesized to improve exercise performance, increase muscle protein synthesis, prevent muscle tissue breakdown, increase energy, increase cognition, enhance your pump, and take your workouts to the next level! Our product is synthesized utilizing the latest scientific research and formulated with optimal ratios of branch chain amino acids to produce world class results. Our formula is third party independently tested for heavy metals, impurities, made in the USA, GMP certified, and produced in an FDA registered facility. 1% of the supplements on the market can match our world class standards.

 

Formula Ingredient Deck	Benefits Of Each Ingredient
Vitamin B6 pyridoxal 5′-phosphate (PLP)	Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40). Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40). May support blood sugar regulation in women with gestational diabetes (40). cofactor for enzymes involved in DNA metabolism (40).
Niacin (Vitamin B3)	Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9). Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9). Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9). Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9). Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn’s disease (10, 11). Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12). Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9). Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9). Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).
Caffeine Anhydrous	Optimizes energy, cognitive function, and mental alertness (24). Supplementation with caffeine has been shown to acutely enhance exercise performance (24).
L-Citrulline Malate	Supports cardiovascular health and exercise performance by increasing the production of l-arginine (34). Increases nitric oxide production, improves exercise performance, and increases blood flow to exercising skeletal muscle (35). Supports strength increases, exercise endurance, and recovery (34,35). May reduce blood pressure by increasing vascular function (34).
Bioperine	Increases absorption of amino acids and curcumin.
Folate (Folic Acid)	May support proper cell growth and DNA synthesis (65).
Vitamin B-12 (Methylcobalamin)	Metabolically active, methylated form of Vitamin B12 needed for proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53). Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51). May prevent vitamin b-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).
Creatine Monohydrate	Optimizes exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47). Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (47,50). Vital in bioenergetics (metabolic activity) of the brain (50). Fuels CD8 and CD4 T- cell-mediated immunity (immune cells) in cancer tissue (48,49). Supports cognition and focus via replenishment of cerebral storage of creatine (creatine in the brain) (50). Supports cognitive health in brain creatine deficiency associated with neurodegenerative diseases (50). Supports cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (50).
N-Acetyl Tyrosine	Supports memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60). The precursor to dopamine and is vital for dopamine synthesis in the brain (60). Supports cognitive function in individuals with high amounts of stress and anxiety (60,61). Increases dopamine levels in highly stressed individuals (60).
Choline Bitrate	Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63). Serves as a methyl donor and as a precursor for the production of cell membranes (62). Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64). Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62). Reduces the concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62).
DMAE Bitrate	Increases acetylcholine levels in the brain.
L-Theanine	A unique non-protein amino acid found in green tea (Camellia sinensis) (53). Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (53). Aids as an antidepressant due to partial antagonism for the N-methyl-D-aspartate receptor manifesting its cognitive optimizing effects (53). Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (54).
Bacopa Monnieri	Supports cognitive function, memory, alertness, and aids as an anti-stress agent (57). May combat inflammatory conditions such as asthma, bronchitis, dropsy, and rheumatism (56,59). Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (58,59,). A promising candidate for the development of novel therapeutics that target neuroinflammation and have the potential for treating a wide range of CNS disorders including Alzheimer’s disease, depression, and schizophrenia (59).

 

Proper Use of This Supplement

Suggested Use: Stir 1 rounded scoop with 6-8ounces of cold water and consume 30-45 minutes before beginning activity.

 

Our Formula                Vs        Other Formulas on the Market.
1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.	1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third-party tested have been removed by FDA due to high levels of heavy metals.
2. Utilizes efficacious evidence-based dosages with optimal ratios of amino acids, nootropics, and pump enhancers to support exercise performance and recovery.	2. Use low amounts of cheap forms of amino acids, nootropics, and pump enhancers that result in poor absorption and muscle growth, recovery, and exercise performance.

 

Sources:

24. 24. Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
    25. Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
    26. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340
    27. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002
    28. Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. doi:10.1186/s12970-017-0173-z
    29. Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y. C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., To, A., & Yang, L. (2019). Creatine uptake regulates CD8 T cell antitumor immunity. The Journal of experimental medicine, 216(12), 2869–2882. https://doi.org/10.1084/jem.20182044
    30. Kazak, L., & Cohen, P. (2020). Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature reviews. Endocrinology, 16(8), 421–436. https://doi.org/10.1038/s41574-020-0365-5
    31. Ebrahimi, K., Jourkesh, M., Sadigh-Eteghad, S., Stannard, S. R., Earnest, C. P., Ramsbottom, R., Antonio, J., & Navin, K. H. (2020). Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer’s Diseases. Diseases (Basel, Switzerland), 8(2), 18. https://doi.org/10.3390/diseases8020018
    32. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B₁₂in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
    33. Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill–a review. Anaesthesia and intensive care, 44(4), 447–452. https://doi.org/10.1177/0310057X1604400410
    34. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency – A 21st century perspective. Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
    35. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
    36. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
    37. Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. Journal of ethnopharmacology, 197, 92–100. https://doi.org/10.1016/j.jep.2016.07.073
    38. Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528–535. https://doi.org/10.1016/j.jep.2013.11.008
    39. Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019). Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst – A review on its mechanistic aspects. Complementary therapies in medicine, 44, 68–82. https://doi.org/10.1016/j.ctim.2019.03.016
    40. Lurie DI CJ. The role of bacopa monnieri in inflammatory and neurodegenerative diseases. In: Motohashi N, editor. Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits.Nova Science Publishers; New York, USA: 2015a. pp. 27–61. [Google Scholar]
    41. Hoffer, L. J., Sher, K., Saboohi, F., Bernier, P., MacNamara, E. M., & Rinzler, D. (2003). N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition. JPEN. Journal of parenteral and enteral nutrition, 27(6), 419–422. https://doi.org/10.1177/0148607103027006419
    42. Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019). Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell, 18(6), e13037. https://doi.org/10.1111/acel.13037
    43. Jadavji, N. M., Emmerson, J. T., MacFarlane, A. J., Willmore, W. G., & Smith, P. D. (2017). B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of disease, 103, 89–100. https://doi.org/10.1016/j.nbd.2017.04.001
    44. Jacobson, S. W., Carter, R. C., Molteno, C. D., Stanton, M. E., Herbert, J. S., Lindinger, N. M., Lewis, C. E., Dodge, N. C., Hoyme, H. E., Zeisel, S. H., Meintjes, E. M., Duggan, C. P., & Jacobson, J. L. (2018). Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcoholism, clinical and experimental research, 42(7), 1327–1341. https://doi.org/10.1111/acer.13769
    45. Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., & Raiten, D. J. (2015). Biomarkers of Nutrition for Development-Folate Review. The Journal of nutrition, 145(7), 1636S–1680S. https://doi.org/10.3945/jn.114.206599
    47. Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
    48. Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
    49. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340
    50. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002
    51. Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. doi:10.1186/s12970-017-0173-z
    52. Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y. C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., To, A., & Yang, L. (2019). Creatine uptake regulates CD8 T cell antitumor immunity. The Journal of experimental medicine, 216(12), 2869–2882. https://doi.org/10.1084/jem.20182044
    53. Kazak, L., & Cohen, P. (2020). Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature reviews. Endocrinology, 16(8), 421–436. https://doi.org/10.1038/s41574-020-0365-5
    54. Ebrahimi, K., Jourkesh, M., Sadigh-Eteghad, S., Stannard, S. R., Earnest, C. P., Ramsbottom, R., Antonio, J., & Navin, K. H. (2020). Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer’s Diseases. Diseases (Basel, Switzerland), 8(2), 18. https://doi.org/10.3390/diseases8020018
    55. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B₁₂in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
    56. Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill–a review. Anaesthesia and intensive care, 44(4), 447–452. https://doi.org/10.1177/0310057X1604400410
    57. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency – A 21st century perspective. Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
    58. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
    59. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
    60. Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. Journal of ethnopharmacology, 197, 92–100. https://doi.org/10.1016/j.jep.2016.07.073
    61. Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528–535. https://doi.org/10.1016/j.jep.2013.11.008
    62. Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019). Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst – A review on its mechanistic aspects. Complementary therapies in medicine, 44, 68–82. https://doi.org/10.1016/j.ctim.2019.03.016
    63. Lurie DI CJ. The role of bacopa monnieri in inflammatory and neurodegenerative diseases. In: Motohashi N, editor. Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits.Nova Science Publishers; New York, USA: 2015a. pp. 27–61. [Google Scholar]
    64. Hoffer, L. J., Sher, K., Saboohi, F., Bernier, P., MacNamara, E. M., & Rinzler, D. (2003). N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition. JPEN. Journal of parenteral and enteral nutrition, 27(6), 419–422. https://doi.org/10.1177/0148607103027006419
    65. Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019). Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell, 18(6), e13037. https://doi.org/10.1111/acel.13037
    66. 63 Jadavji, N. M., Emmerson, J. T., MacFarlane, A. J., Willmore, W. G., & Smith, P. D. (2017). B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of disease, 103, 89–100. https://doi.org/10.1016/j.nbd.2017.04.001
    67. Jacobson, S. W., Carter, R. C., Molteno, C. D., Stanton, M. E., Herbert, J. S., Lindinger, N. M., Lewis, C. E., Dodge, N. C., Hoyme, H. E., Zeisel, S. H., Meintjes, E. M., Duggan, C. P., & Jacobson, J. L. (2018). Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcoholism, clinical and experimental research, 42(7), 1327–1341. https://doi.org/10.1111/acer.13769
    68. Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., & Raiten, D. J. (2015). Biomarkers of Nutrition for Development-Folate Review. The Journal of nutrition, 145(7), 1636S–1680S. https://doi.org/10.3945/jn.114.206599
    70. DO NOT EXCEED 2 SCOOPS IN ANY 24 HOUR PERIOD.CAUTION: Do not use if under age 18. Do not use if you are pregnant or nursing. Consult a medical doctor before use if you have any medical condition or family history of any disease, including (but not limited to) hypotension, hypertension, heart, liver, or thyroid disease, diabetes, psychiatric disease, asthma, pernicious anemia, anxiety, depression, seizure disorder, cardiac arrhythmia, stroke, prostate enlargement, or if you are taking any prescription drug.
    72. KEEP OUT OF REACH OF CHILDREN.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Administration. This product is not intended to diagnose, treat, cure or prevent any disease.